Methods and compositions including conjugated dnazymes
Assignee1E Therapeutics Ltd.
InventorsAlexander ROSENBERG, Itzhak ZANDER, Guy SHMUL
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Abstract
Provided herein are DNAzymes conjugated to a penetration-enhancing moiety and methods of facilitating entry of DNAzymes into bacteria, utilizing same. Also provided are methods of targeting bacterial genes, methods of treating or inhibiting the progression of bacterial infections, and methods of increasing susceptibility of bacteria to an antibiotic, using the described conjugated DNAzymes, which are optionally capable of silencing at least one target gene of bacteria and/or rendering bacteria susceptible to antibiotic treatment.
Claims24
A DNAzyme conjugated to a penetration-enhancing moiety, wherein said penetration-enhancing moiety comprises a benzodihydropyran ring system and an alkyl moiety, and wherein said DNAzyme is conjugated to said benzodihydropyran ring system.
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A method of treating or preventing a bacterial infection in a subject in need thereof or of aiding in the treatment or prevention of a bacterial infection in a subject in need thereof, said method comprising administering to the subject a DNAzyme conjugated to a penetration-enhancing moiety, wherein said penetration-enhancing moiety comprises a benzodihydropyran ring system and an alkyl moiety, and wherein said DNAzyme is conjugated to said benzodihydropyran ring system, thereby treating or preventing the bacterial infection in the subject.
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A method of reducing a biofilm presence on a medical devise in a subject in need thereof, said method comprising administering a DNAzyme conjugated to a penetration enhancing moiety comprising a steroid, wherein optionally said steroid comprises cholesterol.
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Dependencies are inferred from the claim text.