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US 2026/0167959 A1Published application
Aptazyme-based regulatable gene expression systems
AssigneeRejuvenate Bio
InventorsNoah Davidsohn, Louis Metzger, Rokib Hasan
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Abstract
Provided herein are ligand responsive ribozymes comprising a ligand responsive aptamer linked to a self-cleaving ribozyme for the ligand-dependent regulation of gene expression and methods of use thereof.
Claims50
A polynucleotide comprising a transgene operably linked to a ligand responsive ribozyme, wherein the ligand responsive ribozyme comprises a nucleic acid sequence having at least 85% sequence identity to the sequence set forth in any one of SEQ ID NOs:
- 1-50.
A ligand responsive ribozyme comprising a nucleic acid sequence having at least 85% identity to the sequence set forth in any one of SEQ ID NOs:
- 1-50.
Dependencies are inferred from the claim text.