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US 2026/0167955 A1Published application
Method for discovering cell surface antigens for novel antibodies
AssigneesSurvivant Biologics, University of Ulsan Foundation for Industry Cooperation
InventorsSu Hwan CHANG, Yong Sub KIM, Eun A CHOI
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Abstract
The present disclosure relates to a method for discovering cell surface antigens for novel antibodies. According to a screening method of an aspect, cell surface antigens that bind to novel antibodies may be accurately screened. Moreover, the method is effective in efficiently screening cell surface antigens for novel antibodies by using cells that bind well to the novel antibodies.
Claims14
A method for screening cell surface antigens, comprising:
- treating separated cells with a vector to which a guide RNA (gRNA) library for cell surface proteins of the separated cells is introduced to produce vector-treated cells;
- treating the vector-treated cells with a protein having binding ability to the separated cells to produce protein-treated cells;
- and
- obtaining, from the protein-treated cells, cells that have lost binding ability to the protein used in the treating.
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Dependencies are inferred from the claim text.