Biocatalysts for organic synthesis

A biocatalyst for organic synthesis, comprising:

• a. a controlled porosity silica (CPS) as support material, having a pore diameter from about 20 to about 100 nm, wherein the support material comprises an amino-functionalized surface;
• and
• b. one or more catalytically active enzyme(s) immobilized to the amino-functionalized surface by a covalent linker comprising a bond selected from amino, amide and imidoamide.

A biocatalyst for organic synthesis, comprising:

• a. a controlled porosity silica (CPS) as support material, having a pore diameter from about 20 to about 100 nm, wherein the support material comprises an amino-functionalized surface;
• and
• b. one or more catalytically active enzyme(s) immobilized to the surface via non-covalent interactions.

A biocatalyst for organic synthesis, comprising:

• a. a controlled porosity silica (CPS) as support material, having a pore diameter from about 20 to about 100 nm, wherein the support material surface comprises at least two different coatings, of which at least one provides an amino functionalized surface;
• and
• b. one or more catalytically active enzyme(s) immobilized on the surface, optionally by a covalent linker comprising a bond selected from amino, amide and imidoamide.