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US 2026/0167915 A1Published application
System and method for ex-vivo development
AssigneeBecoming Bio, Inc.
InventorJack Andrew Cohen
Life of this patent
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Abstract
The system can include: a set of incubation modules, a fluid module, a gas module, a sensor module, and a processing system. The method can include incubating a set of biological specimens using the system. The system and/or method can function to incubate (e.g., gestate) a set of biological specimens (e.g., embryos) from a one-cell stage through full development or any range therebetween. The set of biological specimens can optionally be used for therapeutics.
Claims20
A system for developing an embryo, the system comprising:
- a well having a base surface defining a first opening, wherein the embryo is housed within the well;
- a gel, wherein the gel is disposed between the embryo and the base surface of the well;
- a first fluid circuit configured to supply a first media to the well;
- and
- a second fluid circuit comprising a channel coupled to the base surface of the well, wherein a second media passes through the channel, the channel comprising a top surface defining a second opening, wherein the first opening at least partially overlaps with the second opening.
2 more elements
A system for developing a set of embryos, the system comprising:
- a first reservoir housing a first media;
- a set of pumps configured to deliver a set of media components to the first reservoir;
- a set of incubation modules, wherein incubation module is configured to house an embryo in the set of embryos, wherein each incubation module comprises:
- a well having a base surface, wherein an embryo in the set of embryos is housed within the well;
- a gel, wherein the gel is disposed between the embryo and the base surface of the well;
- and
- a first fluid circuit connected to the first reservoir, the first fluid circuit configured to supply the first media to the well;
- a gas control system configured to control a composition of gas within the well of each incubation module;
- an imaging device configured to collect a set of images of each embryo in the set of incubation modules;
- a processing system configured to:
- using a model, determine a developmental stage of the embryo based on the set of images;
- based on the developmental stage of the embryo, control the set of pumps;
- and
- based on the developmental stage of the embryo, control the gas control system.
11 more elements
Dependencies are inferred from the claim text.