Antigen-binding molecule containing modified fc region
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Naoka Hironiwa, Shojiro Kadono, Atsushi Matsuo, Taichi Kuramochi, Futa Mimoto
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Abstract
The present inventors have successfully prepared an antibody Fc region dimer that has binding activity against each of an antigen and FcγR, but does not bind to the antigen and the FcγR at the same time, and a polypeptide comprising the Fc region dimer. The present invention enables the preparation of a multispecific binding polypeptide capable of avoiding an adverse reaction that may be caused by its binding to an antigen and FcγR at the same time. Thus, the present invention provides a polypeptide suitable as a drug.
Claims42
1-38. (canceled)
A polypeptide comprising an Fc region dimer made up of a first Fc region and a second Fc region, wherein the Fc region dimer comprises (a) an antigen-binding site that binds an antigen, and (b) an FcγR-binding site, and wherein the Fc region dimer does not bind to the antigen and FcγR at the same time.
Dependencies are inferred from the claim text.