Molecules for controlling autoimmune response
AssigneeMerida Biosciences, Inc.
InventorsDario A. Gutierrez, Meike E. W. Logtenberg, Allan D. Capili, Adrienne Marie Rothschilds
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Abstract
The present disclosure provides inter alia, molecules comprising an autoantibody-binding domain and at least one modified Fc domain. The present disclosure also provides methods and compositions that allow for selective depletion and/or neutralization of pathogenic autoantibodies.
Claims26
1-199. (canceled)
A molecule comprising a first polypeptide and a second polypeptide, wherein the first polypeptide comprises the amino acid sequence of SEQ ID NO:
- 245 and the second polypeptide comprises the amino acid sequence of SEQ ID NO:
- 248.
A nucleic acid comprising a first nucleotide sequence encoding a first polypeptide and a second nucleotide sequence encoding a second polypeptide, wherein the first polypeptide comprises the amino acid sequence of SEQ ID NO:
- 245 and the second polypeptide comprises the amino acid sequence of SEQ ID NO:
- 248.
Dependencies are inferred from the claim text.