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US 2026/0167674 A1Published application
Ace2 homologous peptide sequences
AssigneeBezmialem Vakif Universitesi
InventorsSERDAR UYSAL, MOHAMMAD ASIF KHAN
Life of this patent
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Abstract
Peptide sequences that are ACE2 homologues are provided. Compared to the wild-type ACE2 in the host, the peptide sequences bind with higher affinity to the receptor-binding domain (RBD), thus inhibiting this interaction by competitively inhibiting the binding of the virus RBD region of SARS-COV-2 with the human ACE2. The peptide sequences can be included in a pharmaceutical composition.
Claims9
An angiotensin converting enzyme 2 (ACE2) homologous peptide, comprising one of the following sequences:
- (SEQ ID NO:
- 1)
- QEQAQTYLDGYNKTYQDLVYKDNLAQWTLNT
- (SEQ ID NO:
- 2)
- VTQQAQMFLEEFNRRAENISYESSLASWDYNT
- (SEQ ID NO:
- 3)
- EENAKTFLNNFNQEAEDLSYQSSLASWNYNT
- (SEQ ID NO:
- 4)
- VENKANEFLQKFDEEATRRMYQYSLASWAYNT
- (SEQ ID NO:
- 5)
- RQQAQTYLDSYNKTYQDLIYKDNLAQWTLNT
- (SEQ ID NO:
- 6)
- VTQQAAEFLLQFNINAENRSYESSLASWDYNT
- (SEQ ID NO:
- 7)
- VPQNVTTFLNQFNQNAEGLYYESSLASWAYNT
18 more elements
Dependencies are inferred from the claim text.