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AssigneeT-E Meds Inc.
InventorsHsing-Mao CHU, Chi-Jiun PENG, Cédric GRAUFFEL, Tse-Wen CHANG, Tzu-Chen LIN, Wei-Chen LIN
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Provided herein is a compound having the structure of formula (I), wherein X1 is an acidic β-homo-amino acid or an acidic α-methyl-amino acid; X2 is valine (V) or leucine (L); X3 is citrulline, alanine (A) or lysine (L); A1, A2 and A3 are independently nil or a polyethylene glycol (PEG) moiety comprising 1 to 24 repeats of ethylene glycol (EG) unit; and A3 is nil when X3 is not lysine. Also provided herein are linker units including the present compound of formula (I) for linking effector elements, and antibody-drug conjugates (ADCs) including the present linker units.
A compound having the structure of formula (I),
An antibody-drug conjugate (ADC) comprising an antibody and 2 to 8 linker units independently linked to the antibody, wherein each of the linker units is the linker unit of claim 16.
Dependencies are inferred from the claim text.