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US 2026/0167657 A1Published application
Amino-imidazole antibacterial compounds
AssigneeHoffmann-La Roche Inc.
InventorsJean-Baptiste Emmanuel BLANC, Patrick DI GIORGIO, Christian KRAMER, Petra SCHMITZ, Theodor Walter Jakob STOLL, Lorenz Michael URNER, William John ZUERCHER
Life of this patent
Estimating the term…
Abstract
Provided herein are amino imidazole compounds useful in treating infections.
Claims49
A compound of formula (I) or (II):
- or a stereoisomer or pharmaceutically acceptable salt thereof, wherein
- Ring A is 4- to 8-membered RA-substituted or unsubstituted heterocyclyl;
- RA is halogen, NH2, OH, unsubstituted C1-3alkyl, or unsubstituted C1-3haloalkyl;
- m is 0 or 1;
- R1 is N(R6)2, R6-substituted or unsubstituted C1-6alkyl, R6-substituted or unsubstituted C1-3haloalkyl, R6-substituted or unsubstituted C3-6cycloalkyl, or R6-substituted or unsubstituted 4- to 8-membered heterocyclyl comprising 1 or 2 heteroatoms independently selected from N, O, S, or SO2;
- each R6 is independently hydrogen, halogen, CH(═NH)(NH2), (═NH), N(R7)2, OR7, NHC(O)R7, C(O)OR7, R7-substituted or unsubstituted C1-6alkyl, R7-substituted or unsubstituted C1-6haloalkyl, R7-substituted or unsubstituted C3-6 cycloalkyl, or R7-substituted or unsubstituted 4- to 6-membered heterocyclyl;
- or
- wherein two or more R6 groups together form a C1-2 bridge;
- each R7 is hydrogen, halo, OH, COOH, (═NH), NH2, unsubstituted C1-3alkyl, unsubstituted C1-3alkyoxy, unsubstituted C1-3alkylaryl, unsubstituted C1-6alkyl heterocyclyl, or unsubstituted 4- to 6-membered heterocyclyl;
- R1a is a moiety of formula:
- or a stereoisomer thereof;
- R1b is O—C1-3alkyaryl, unsubstituted 5- to 7-membered heterocyclyl;
- R2 is hydrogen, halogen, unsubstituted C1-3alkyl, or unsubstituted C1-3haloalkyl;
- R3 is a moiety of formula:
- or a stereoisomer thereof
- L is absent, —O—, or —NR8b—;
- R8 is R8a-substituted or unsubstituted C1-6alkyl, R8a-substituted or unsubstituted C1-3haloalkyl, or R8a-substituted or unsubstituted C3-6cycloalkyl;
- wherein when L is absent R8 is
- R8a is unsubstituted C1-3alkyl, OH, or OR8b wherein R8b is unsubstituted C1-3alkyl;
- R8b is hydrogen or unsubstituted C1-3alkyl;
- R9 is halo, CN, unsubstituted C1-6alkyl, unsubstituted C1-3haloalkyl, unsubstituted C1-6alkoxy, or unsubstituted cyclopropyl;
- n is 0, 1, or 2;
- R10 is R10A-substituted or unsubstituted C1-6alkyl, R10A-substituted or unsubstituted C2-6alkenyl, R10A-substituted or unsubstituted C2-6alkynl, R10A-substituted or unsubstituted C1-3haloalkyl, or R10A-substituted or unsubstituted C3-6cycloalkyl;
- R10A is halo, CN, OH, OCH3, unsubstituted C1-3haloalkyl, or R10B-substituted or unsubstituted C3-5cycloalkyl, or wherein 2 R10A groups together form a R10B-substituted or unsubstituted C3-4spirocycle;
- R10B is halo or unsubstituted C1-3haloalkyl;
- R11 is halo or unsubstituted C1-3haloalkyl;
- and
- R4 is hydrogen, halo, or unsubstituted C1-3alkyl.
25 more elements
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A compound of Table 1 or a stereoisomer or pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.