Phosphoramidate compounds and uses thereof

A compound of Formula II, or a pharmaceutically acceptable salt thereof:

• wherein:
• X is O, S, NR10, an optionally substituted C1-4 alkylene, or an optionally substituted C1-4 heteroalkylene, wherein R10 is hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted 3-6 membered ring, or a nitrogen protecting group;
• Y and Z are each independently O, S, NR11 or CR12, as valency permits, provided that the 5-membered ring containing Y and Z is aromatic;
• wherein:
• (i) R11 is hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted 3-6 membered ring, or a nitrogen protecting group, R12 is hydrogen, halogen, CN, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 heteroalkyl, or an optionally substituted 3-6 membered ring;
• or
• (ii) R11 or R12, as applicable, together with R1 and the intervening atoms are joined together to form an optionally substituted 5-8 membered ring;
• R1 is defined in (ii) or is hydrogen, deuterium, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, or optionally substituted C2-4 alkynyl;
• R2 and R4 are each independently hydrogen, halogen (e.g., F), optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C1-4 alkoxy, or an optionally substituted 3-5 membered ring;
• R3 is hydrogen, an optionally substituted C1-4 alkyl, or an optionally substituted 3-10 membered ring;
• R6 is hydrogen, deuterium, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, or optionally substituted C2-4 alkynyl;
• the integers n1 and n2 are each independently 0, 1, 2, 3, or 4;
• and
• each of Ra and Rb at each occurrence is independently an optionally substituted C1-4 alkyl or an optionally substituted C1-4 heteroalkylene;
• or two instances of Ra or two instances of Rb, together with the intervening atoms, are joined together to form an optionally substituted 3-6 membered ring, and any remaining instances of Ra and/or Rb are as defined above.

A compound of Formula III, or a pharmaceutically acceptable salt thereof:

• (1) R1 is hydrogen, deuterium, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, or optionally substituted C2-4 alkynyl;
• and
• R2, R4, and R5 are each independently hydrogen, halogen (e.g., F), optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C1-4 alkoxy, or an optionally substituted 3-5 membered ring;
• or
• (2) R1 and R2, together with the intervening atoms, are joined to form an optionally substituted 4-8 membered carbocyclic or heterocyclic ring, and
• R4 and R5 are as defined in (1);
• or
• (3) R1 and R5, together with the intervening atoms, are joined to form an optionally substituted 4-8 membered carbocyclic or heterocyclic ring;
• and
• R2 and R4 are as defined in (1);
• or
• (4) R4 and R5, together with the intervening atoms, are joined to form an optionally substituted 4-8 membered ring;
• and
• R1 and R2 are as defined in (1) or (2);
• and
• wherein:
• X is O, S, NR10, an optionally substituted C1-4 alkylene, or an optionally substituted C1-4 heteroalkylene, wherein R10 is hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted 3-6 membered ring, or a nitrogen protecting group;
• AR represents an optionally substituted arylene or optionally substituted heteroarylene;
• R3 is hydrogen, an optionally substituted C1-4 alkyl, or an optionally substituted 3-10 membered ring;
• Rl′ is hydrogen, deuterium, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, or optionally substituted C2-4 alkynyl;
• R6 and R6′ are each independently hydrogen, deuterium, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, or optionally substituted C2-4 alkynyl;
• the integers n1 and n2 are each independently 0, 1, 2, 3, or 4;
• and
• each of Ra and Rb at each occurrence is independently an optionally substituted C1-4 alkyl or an optionally substituted C1-4 heteroalkylene;
• or two instances of Ra or two instances of Rb, together with the intervening atoms, are joined together to form an optionally substituted 3-6 membered ring, and any remaining instances of Ra and/or Rb are as defined above.