System for removing protein bound uremic toxins during hemodialysis

Abstract

Systems and methods for physiologically safe removal of protein-bound uremic toxins (PBUTs) from blood proteins, including albumin, during dialysis. A dialysis system for removal of PBUTs includes a protein-bind column operably connected to at least a portion of a plasma stream. During use, the column captures albumin and PBUTs complexed with the captured albumin are released from the albumin with a toxin release step into a waste stream or dialyzer. The captured albumin is then released from the column with a protein release step and the released albumin reenters the plasma stream and the patient's body. Compositions used for release steps, including the protein release step, are physiologically safe for entry into the patient's body. Since the toxins are removed from the albumin, the patient has a lower risk of health complications due to the presence of PBUTs in the bloodstream.

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