US 2026/0166196 A1 · ROS-RESPONSIVE THERONOSTIC BIOSENSOR

Abstract

The theranostic wound dressing that combines diagnostic functions with therapeutic actions, including the targeted release of antibiotics, which enhances treatment efficiency and reduces the likelihood of prolonged infections or the development of antibiotic resistance. The present invention provides a theranostic wound dressing, that includes citric acid and a modified hemicyanine dye immobilized within polymer nanofibers formed as a nanofibrous matrix, the matrix immobilizing nanoparticles encapsulating at least one antimicrobial compound. The nanoparticles are structurally responsive to reactive oxygen species (ROS) to effectively release an antimicrobial. The hemicyanine dye is adapted to react with a color-change in the presence of pathogenic enzymes. Ester bonds present in the hemicyanine dye are cleavable by pathogenic enzymes secreted by pathogenic bacteria and fungi. Cleaving the ester bonds present in the hemicyanine dye increases intramolecular charge transfer in the hemicyanine dye and induces the color-change.

Claims25

Dependent claims

A theranostic wound dressing, comprising:

organic acid and a hemicyanine dye immobilized within polymer nanofibers formed as a nanofibrous matrix:
nanoparticles immobilized within said nanofibrous matrix, said nanoparticles comprising at least one antimicrobial compound encapsulated within the nanoparticles,
wherein, said nanoparticles further comprise a polyethylene glycol b-polypropylene sulfide polymer (mPEG45-b-PPS60) which changes structure in the presence of reactive oxygen species (ROS) said structural change allowing release of said compound, and
wherein, said hemicyanine dye is adapted to react with a color-change when exposed to pathogenic enzymes above specific concentrations of presence.

1 more element

A theranostic wound dressing, comprising:

citric acid and a modified hemicyanine dye immobilized within polymer nanofibers comprising polyurethane and polypyrrolidone formed as a nanofibrous matrix by electrospinning;
nanoparticles immobilized within said nanofibrous matrix, said nanoparticles comprising mPEG45-b-PPS60 polymer encapsulating at least one antimicrobial compound,
wherein, said nanofibers fibers in said nanofibrous matrix comprise citric acid in the range of 3.8% to 4.2% and exhibit an average diameter of 412±140 nm,
wherein, said nanofibrous matrix has a thickness in the range of 380-420 μm,
wherein, said mPEG45-b-PPS60 polymer nanoparticles when freshly assembled have a spherical morphology with an average diameter of 213.9±29.5 nm,
wherein, said nanoparticles are structurally responsive to reactive oxygen species (ROS), and
wherein, said hemicyanine dye is adapted to react with a color-change in the presence of pathogenic enzymes.

4 more elements

Dependencies are inferred from the claim text.

Ros-responsive theronostic biosensor

Life of this patent

Ros-responsive theronostic biosensor

Life of this patent

Abstract

Claims25