Near-infrared responsive bilirubin composite nanoparticle-loaded periodontal microneedle and preparation method thereof

Abstract

A near-infrared responsive bilirubin composite nanoparticle-loaded periodontal microneedle and a preparation method thereof are provided. A near-infrared responsive bilirubin composite nanoparticle includes a bilirubin-gelatin composite nanoparticle, wherein a surface of the bilirubin-gelatin composite nanoparticle is coated with a macrophage cell membrane and an organic-metal coordination supramolecular network coating in sequence; an outer surface of the near-infrared responsive bilirubin composite nanoparticle is modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)] (DSPE-PEG-FA); in the bilirubin-gelatin composite nanoparticle, bilirubin and gelatin are covalently bonded via an amide bond; and in the organic-metal coordination supramolecular network coating, an organic ligand is anthocyanin, and a coordinating metal ion is ferric ion.

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