Methods of identifying senotherapeutic targets and treating muscle degradation
AssigneeCenter for Neuromusculoskeletal Restorative Medicine Limited
InventorsHuating Wang, Yang Li, Chuhan Li
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Abstract
A method for identifying senotherapeutic targets includes the steps of obtaining multiomics data from senescent cells to provide a senescence atlas, utilising the senescence atlas to identify molecular markers associated with cellular senescence, comparing the identified molecular markers with senescence-associated secretory phenotypes (SASPs) and senescence biomarkers, and identifying potential senotherapeutic targets involved in tissue degradation.
Claims54
A method for identifying senotherapeutic targets, comprising the steps of:
- obtaining multiomics data from senescent cells to provide a senescence atlas,
- utilising the senescence atlas to identify molecular markers associated with cellular senescence,
- comparing the identified molecular markers with senescence-associated secretory phenotypes (SASPs) and senescence biomarkers, and
- identifying potential senotherapeutic targets involved in tissue degradation.
A method of treating muscle degradation in a subject, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof:
The use of a compound of Formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in the manufacture of a medicament for the treatment of muscle degradation in a subject:
A method of treating muscle degradation in a subject, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (II), or a pharmaceutically acceptable salt, solvate, or hydrate thereof:
The use of a compound of Formula (II), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in the manufacture of a medicament for the treatment of muscle degradation in a subject:
Dependencies are inferred from the claim text.