Treatment of meniere's disease
AssigneeSound Pharmaceuticals Incorporated
InventorJonathan KIL
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Abstract
Disclosed herein are novel methods and compositions for treating MD and/or endolymphatic hydrops. The composition comprises ebselen and optionally one or more a glutathione peroxidase (GPx) modulator or mimic compounds and/or one or more prescription diuretic compounds. Also disclosed are methods of increasing GPx activity and reducing free radical species and cochlear or vestibular inflammation in a subject.
Claims40
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A method of treating, and/or ameliorating Meniere's disease in a subject comprising administering to a subject in need thereof an effective amount of a composition comprising ebselen or a pharmaceutically acceptable salt or solvate thereof in combination with one or more diuretic compounds.
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A method of treating, and/or ameliorating endolymphatic hydrops in a subject comprising administering to a subject in need thereof an effective amount of a composition comprising ebselen or a pharmaceutically acceptable salt or solvate thereof.
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Dependencies are inferred from the claim text.