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US 2026/0160759 A1Published application
Systems and methods for multiplex detection of biomarkers
AssigneeVeravas, Inc.
InventorsJoshua Caine Soldo, Scott Douglass Bergmann
Life of this patent
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Abstract
Provided herein are methods and systems for multiplex detection and/or measurement of biomarkers of a sample. The methods and systems can be used for rapid disease detection and/or monitoring, vaccine efficacy and immune response monitoring, therapeutic drug monitoring, and/or therapeutic safety and efficacy monitoring.
Claims21
1-119. (canceled)
An assay method comprising:
- (a) contacting a sample comprising a biomarker with a biomarker capture particle, thereby capturing the biomarker by the biomarker capture particle to yield a captured biomarker;
- and
- (b) binding the captured biomarker with a detection composition, wherein the detection composition has an interference removed by an interference capture composition.
An assay method comprising:
- (a) contacting a sample comprising a biomarker with a first agglutination particle comprising a first color and a second agglutination particle comprising a second color, wherein the first agglutination particle and the second agglutination particle aggregate upon binding the biomarker in the sample to form an aggregated agglutination particle;
- and
- (b) detecting the aggregated agglutination particle.
An assay method comprising:
- (a) contacting a sample comprising a biomarker with (i) a plurality of magnetic particles and (ii) a plurality of non-magnetic particles, wherein the plurality of magnetic particles are larger in size than the plurality of non-magnetic particles, wherein a magnetic particle of the plurality of magnetic particles and a non-magnetic particle of the plurality of non-magnetic particles form a complex upon binding the biomarker;
- and
- (b) detecting the complex.
Dependencies are inferred from the claim text.