Chondroitin Sulfate and Heparan Sulfate as Biomarkers for Discriminating Osteoarthritis and Rheumatoid Arthritis
AssigneeElypta AB
InventorsFrancesco Gatto, Fredrik Härenstam
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of screening for osteoarthritis (OA) and rheumatoid arthritis (RA) and methods of discriminating between OA and rheumatoid arthritis RA in a subject having arthritis or in a subject suspected of having arthritis, said methods comprising determining the level in a body fluid sample of one or more glycosaminoglycan (GAG) property in accordance with the invention. The present invention also provides methods for monitoring the progression of OA or RA in a subject having arthritis.
Claims23
A method of discriminating between osteoarthritis (OA) and rheumatoid arthritis (RA) in a subject having arthritis or in a subject suspected of having arthritis, said method comprising:
- determining the level and/or chemical composition of one or both of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and heparan sulfate (HS) in a urine sample,
- wherein said determining the level and/or chemical composition of one or both of said GAGs comprises determining the level of one or more GAG property selected from the group consisting of:
- (i) 4S CS, (ii) NS HS, (iii) 0S HS, (iv) total concentration of CS, and (v) total concentration of HS,
- wherein said sample has been obtained from said subject.
A method of monitoring the progression of osteoarthritis (OA) or rheumatoid arthritis (RA) in a subject having arthritis, said method comprising:
- determining the level and/or chemical composition of one or both of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and heparan sulfate (HS) in a urine sample,
- wherein said determining the level and/or chemical composition of one or both of said GAGs comprises determining the level of one or more GAG property selected from the group consisting of:
- (i) 4S CS,
- (ii) NS HS,
- (iii) 0S HS,
- (iv) total concentration of CS;
- and
- (v) total concentration of HS,
- wherein said sample has been obtained from said subject.
Dependencies are inferred from the claim text.