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US 2026/0160753 A1Published application
Three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening
AssigneeOregon State University
InventorsKaitlin C. Fogg, Ines Alexandra Cadena, Mina Buchanan, Alyssa Grace Almer, Molly A. Jenne, Conor Gage Harris
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Abstract
A dual hydrogel system, comprising a first hydrogel that is a crosslinked gelatin hydrogel, a second hydrogel that is a crosslinked poly(ethylene glycol) hydrogel, endothelial cells intermediate and substantially coextensive with the first and second hydrogels, and endometrial cancer cells disposed on a first surface of the second hydrogel. A method for assessing the effectiveness of a therapeutic agent for the treatment of endometrial cancer using the hydrogel system.
Claims14
A hydrogel system, comprising:
- (a) a first hydrogel having a first surface and an opposing second surface, wherein the first hydrogel is a crosslinked gelatin hydrogel comprising collagen I and fibrin;
- (b) a second hydrogel having a first surface and an opposing second surface, wherein the second hydrogel is a crosslinked poly(ethylene glycol) hydrogel comprising collagen IV, fibronectin, and laminin, wherein the second surface (bottom) of the second hydrogel (top) is adjacent the first surface of the first hydrogel;
- (c) endothelial cells intermediate and substantially coextensive with the first surface of the first hydrogel and the second surface of the second hydrogel;
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- (d) endometrial cancer cells disposed on the first surface of the second hydrogel.
2 more elements
Dependencies are inferred from the claim text.