US 2026/0160665 A1 · ACOUSTIC SEPARATION AND LYSING

Abstract

An example system includes a flow cell containing a fluidic channel configured to receive a sample, where the sample includes plasma and blood cells. and one or more acoustic transducers configured to output acoustic waves to the fluidic channel. The one or more acoustic transducers are configured (i) to output acoustic waves in a first frequency range to separate the plasma from the blood cells in the fluidic channel, and (ii) to output acoustic waves in a second frequency range to lyse the blood cells in the fluidic channel. The first frequency range includes higher frequencies than the second frequency range. A spectrometer is configured (i) to perform detection on a region of the fluidic channel containing the plasma separated from the blood cells, and (ii) to perform detection on a region of the fluidic channel where the blood cells have been lysed.

Claims19

Dependent claims

A system comprising:

a flow cell containing a fluidic channel configured to receive a sample, the sample comprising plasma and blood cells;
one or more acoustic transducers configured to output acoustic waves to the fluidic channel, the one or more acoustic transducers being configured (i) to output acoustic waves in a first frequency range to separate the plasma from the blood cells in the fluidic channel, and (ii) to output acoustic waves in a second frequency range to lyse the blood cells in the fluidic channel, the first frequency range comprising higher frequencies than the second frequency range;
and
a spectrometer (i) to perform detection on a region of the fluidic channel containing the plasma separated from the blood cells, and (ii) to perform detection on a region of the fluidic channel where the blood cells have been lysed.

1 more element

A method comprising:

controlling one or more acoustic transducers to output acoustic waves to a fluidic channel containing a sample comprised of plasma and blood cells, the one or more acoustic transducers being controlled to output the acoustic waves in a first frequency range to separate the plasma from the blood cells in the fluidic channel;
obtaining information from a region of the fluidic channel containing the plasma separated from the blood cells;
obtaining a hemolysis measurement for the region of the fluidic channel containing the plasma separated from the blood cells based on the information obtained by the imaging spectrometer from the region of the fluidic channel containing the plasma separated from the blood cells;
controlling the one or more acoustic transducers to output acoustic waves to the fluidic channel after separating the plasma from the blood, the one or more acoustic transducers being controlled to output acoustic waves in a second frequency range to lyse the blood cells in the fluidic channel, the second frequency range comprising lower frequencies than the first frequency range;
obtaining information from a region of the fluidic channel where the blood cells have been lysed;
and
obtaining a co-oximetry measurement for the region of the fluidic channel where the blood cells have been lysed based on the information obtained by the imaging spectrometer from the region of the fluidic channel where the blood cells have been lysed.

4 more elements

Dependencies are inferred from the claim text.

Acoustic separation and lysing

Life of this patent

Acoustic separation and lysing

Life of this patent

Abstract

Claims19