Method for preparing non-toxic liposomes using emulsion-to-liposome transition
AssigneeKnu-Industry Cooperation Foundation
InventorChanghoon CHAI
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Abstract
A method for preparing non-toxic liposomes involves a direct emulsion-to-liposome transition. This process eliminates the need for the use of toxic solvents such as chloroform and chloroform-methanol mixtures, allowing for the production of non-toxic liposomes through a simple and efficient process. As a result, the liposomes prepared by this method offer high economic feasibility, safety, and biocompatibility for applications in various fields, including food, cosmetics, and drug delivery. Additionally, they exhibit high encapsulation efficiency and excellent structural stability, maintaining their initial form and structure over an extended period.
Claims16
A method for preparing non-toxic liposomes, comprising:
- a) an emulsion preparation step comprising the preparation of a water-in-oil (W/O) emulsion comprising lecithin, oil, and water;
- b) a solvent addition step comprising the addition of an ethanol-water mixture to the W/O emulsion to produce a liposome-containing mixture;
- c) an oil removal step comprising the separation and removal of the oil from the liposome-containing mixture, thereby obtaining a liposome-containing ethanol-water mixture;
- and
- d) an ethanol removal step comprising the separation and removal of the ethanol from the liposome-containing ethanol-water mixture, thereby obtaining a liposome-containing aqueous solution.
Dependencies are inferred from the claim text.