US 2026/0159522 A1 · PROCESS FOR THE PREPARATION OF A CHIRAL PYRROLO TRIAZOLE ALCOHOL

Abstract

The invention relates to a novel process for the preparation of chiral pyrrolo triazole alcohols of the formula I wherein X is a halogen atom, n is an integer of 1, 2 or 3 and wherein the spiral bond “” stands for “” or for “” or mixtures of the enantiomers. The chiral pyrrolo triazole alcohols of the formula I are versatile intermediates for the preparation of compounds that have the potential to serve as active pharmaceutical ingredients in drugs.

Claims19

Dependent claims

A process for the preparation of a chiral pyrrolo triazole alcohol of the formula I

wherein X is a halogen atom, n is an integer of 1, 2 or 3 and wherein the spiral bond “” stands for “” or for “” or mixtures of the enantiomers,
comprising the reduction of a ketone of the formula V
wherein X and n are as defined for formula I
a) a metal complex catalyst in the presence of a reducing agent or
b) an oxidoreductase enzyme
to form the chiral alcohol of the formula I.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/415,612Filed 10 Dec 2025

Priority

EP 23180069.919 Jun 2023

Published

11 Jun 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 487/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/4196
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2,4-Triazoles
B01J 31/12
Containing organic compounds or metal hydrides: containing organo-metallic compounds or metal hydrides
C07D 249/12
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…

Process for the preparation of a chiral pyrrolo triazole alcohol

Life of this patent

Process for the preparation of a chiral pyrrolo triazole alcohol

Life of this patent

Abstract

Claims19