Akt3 modulators

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• is
• each occurrence of X1, X2, X3, X4, X5, X6, X7, X8, and X9 is independently CR1 or N;
• each occurrence of R1 is independently selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C4-C14)tricycloalkyl, (C3-C7)heterocycloalkyl, halogenated (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C14)heterotricycloalkyl, (C4-C10)heterospiroalkyl, (C3-C7)cycloalkenyl, (C3-C7)heterocycloalkenyl, (C4-C10)bicycloalkenyl, (C4-C10)heterobicycloalkenyl, (C4-C14)tricycloalkenyl, (C4-C14)heterotricycloalkenyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, —CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra,
• and a partially saturated bicyclic heteroaryl optionally substituted by one or more (C1-C6)alkyl, halogenated (C1-C6)alkyl, —SO2Ra, or —SO2N(Ra)2;
• wherein the (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C4-C14)tricycloalkyl, (C3-C7)heterocycloalkyl, halogenated (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C14)heterotricycloalkyl, (C4-C10)heterospiroalkyl, (C3-C7)cycloalkenyl, (C3-C7)heterocycloalkenyl, (C4-C10)bicycloalkenyl, (C4-C10)heterobicycloalkenyl, (C4-C14)tricycloalkenyl, (C4-C14)heterotricycloalkenyl, aryl, and heteroaryl of R1 are each optionally substituted by one or more (C1-C6)alkyl, halogenated (C1-C6)alkyl, halogen, —ORa, —CN, or —N(Ra)2;
• n is an integer from 0-4 where valence permits;
• Q is C(Ra)2, O, NRa, N(C═O)Ra, or NSO2Ra;
• Y1, Y2, Y3, Y4 and Y5 are each independently N or CR2 where valance permits;
• except that the moiety
• is connected to Y3 or Y5, and when connected to the moiety
• Y3 or Y5 is C;
• each occurrence of R2 is independently selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, SO2N(Ra)2, —N(Ra)SO2Ra,
• each occurrence of R4 is independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, and —N(Ra)2;
• each occurrence of R5 is independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, and —N(Ra)2;
• or alternatively any two R4 groups connected to two adjacent carbons taken together with the two adjacent carbon atoms they are connected to form an optionally substituted (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, or halogenated (C3-C7)heterocycloalkyl;
• m is an integer from 0-3;
• R6 is H, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, aryl, or heteroaryl;
• is
• Z is CR3 or N;
• W is O, NRs or S;
• wherein R8 is H, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, aryl, or heteroaryl;
• each occurrence of R3 is independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, —ORa, —N(Ra)2, —CORa, —CO2Ra, —CON(Ra)2, —CN, —NC, or —NO2;
• each occurrence of R7 is independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, —CON(Ra)2, —CN, —NC, —NO2, —N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra,
• optionally substituted aryl, and optionally substituted heteroaryl;
• or alternatively any two R7 groups taken together with the carbon atom(s) they are connected to form a (C3-C7)cycloalkyl, (C3-C7)heterocycloalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, or heteroaryl;
• p is an integer from 0-3 where valence permits;
• and
• each occurrence of Ra is independently H, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C7)cycloalkyl, aryl, or heteroaryl, or two Ra taken together form a 4-6-membered ring optionally substituted with halogen or (C1-C6)alkyl.