Stilbene derivative, preparation method thereof and application thereof in preparation of drugs for treating psoriasis or ulcerative colitis

Abstract

A stilbene derivative includes a compound II-2 and a compound II-23, and structural formulas of the compound II-2 and the compound II-23 are respectively as follows: The compound II-2 and the compound II-23 can target activation of aryl hydrocarbon receptor (AHR) related pathways, promoting nuclear translocation of AHR. At cellular levels, the compound II-2 and the compound II-23 can reduce secretion of related cytokines, significantly improving skin symptoms and psoriasis area and severity index (PASI) scores of mice in an imiquimod-induced psoriasis mouse model. Compared to lead compound tapinarof, the compound II-2 and the compound II-23 exhibit superior anti-psoriasis activity and lower toxicity. In addition, the compound II-23 can effectively treat ulcerative colitis in mice, reducing inflammatory responses and improving colitis symptoms. The compound II-2 and the compound II-23 can be used to prepare drugs for treating psoriasis and ulcerative colitis.

Dependencies are inferred from the claim text.