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AssigneeManifold Biotechnologies, Inc.
InventorsPierce Ogden, Kathleen Nudel, Erik Swanson, Salvatore Alioto, Alvaro Garcia, Karen Duffy, Alexander Reis, Glenn Gordon Hauk, Naveen Khinduka Mehta, Marshall A. Case
Estimating the term…
Compositions, methods and systems for targeted delivery using one or more shuttles operably linked to one or more cargos (e.g., cargo polypeptides, e.g., cargo oligonucleotides) and subsequent quantification of an abundance of one or more cargos (e.g., proteins) in a mixture (e.g., a complex mixture (e.g., in vivo)) or in a specific cell, tissue, or organ of interest (e.g., in vivo) using barcodes (e.g., peptide barcodes), binders (e.g., polypeptide binders), and binding agents (e.g., phage) are provided herein.
A peptide shuttle, wherein the peptide shuttle has or comprises an amino acid sequence having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% identity to any one of SEQ ID NOs:
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A shuttle component, wherein the shuttle component has or comprises a nucleic acid sequence having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, At least 99%, or 100% identity to any one of SEQ ID NOs:
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A polypeptide comprising:
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A polynucleotide comprising:
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A composition comprising:
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A method for identifying a therapeutic polypeptide or a target polypeptide to treat a disease, disorder, or condition comprising steps of:
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Dependencies are inferred from the claim text.