Immunogenic compositions against influenza
AssigneeFluGen, Inc.
InventorsMichael J. Moser, Yasuko HATTA, Pamuk BILSEL
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Abstract
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include mutant M2 sequences, mutant BM2 sequences, and are useful in immunogenic compositions, e.g., as a quadrivalent vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
Claims11
-17. (canceled)
An immunogenic composition, wherein the composition is a trivalent composition comprising:
- (i) an engineered attenuated H1N1 virus having a mutant M2 gene comprising SEQ ID NO:
- 1;
- (ii) an engineered attenuated H3N2 virus having a mutant M2 gene comprising SEQ ID NO:
- 1;
- and
- (iii) an engineered attenuated B/Victoria virus having a mutant BM2 gene comprising SEQ ID NO:
- 9.
An immunogenic composition, wherein the composition is a trivalent composition comprising:
- (i) an engineered attenuated H1N1 virus having a mutant M2 gene comprising SEQ ID NO:
- 1;
- (ii) an engineered attenuated H3N2 virus having a mutant M2 gene comprising SEQ ID NO:
- 1;
- and
- (iii) an engineered attenuated B/Victoria virus having a mutant BM2 gene comprising SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.