Methods of treatment
OwnerAndrew Chow, Toufigh Gordi +2inventors
InventorsAndrew Chow, Toufigh Gordi, Lisa Rojkjaer, Lucy Yan
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Abstract
Disclosed herein are methods for treating, managing, or ameliorating a disease selected from myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), MPN/MDS, clonal cytopenia of undetermined significance (CCUS), chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). The methods comprise administering to a subject in need thereof a therapeutically effective amount of 1-(4-(4-((3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)ethyl phosphate or a stereoisomer or mixture of stereoisomers, a pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.
Claims20
A method for treating, managing, or ameliorating a myelodysplastic syndrome comprising administering to a subject having a myelodysplastic syndrome 1-(4-(4-((3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)ethyl phosphate, which has the following structure:
- or a stereoisomer or mixture of stereoisomers, a pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof (Compound 1), wherein Compound 1 is orally administered to the subject in an amount of about 100 mg to about 2000 mg per day.
Dependencies are inferred from the claim text.