Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds for treating adenoid cystic carcinoma
AssigneeImmunome, Inc.
InventorDavid Sidransky
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Abstract
The present invention provides methods of treating or suppressing Adenoid Cystic Carcinoma (ACC) or inhibiting ACC tumor growth in subjects by administering compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds, including compounds of Formula (III) or prodrugs thereof.
Claims22
A method of treating or suppressing Adenoid Cystic Carcinoma (ACC) tumor in a subject comprising the step of administering to said subject a composition comprising one or more compounds represented by the structure of Formula (III):
- or prodrugs or salts thereof, wherein:
- R1 is —CH2CF3 or —CH2CH2CF3;
- R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3;
- R3 is H or —CH3;
- Each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3;
- and
- Y is zero, 1, or 2.
A method of inhibiting tumor growth in a subject with an Adenoid Cystic Carcinoma (ACC) tumor comprising the step of administering to said subject a composition comprising one or more compounds represented by the structure of Formula (III):
- or prodrugs or salts thereof, wherein:
- R1 is —CH2CF3 or —CH2CH2CF3;
- R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3;
- R3 is H or —CH3;
- Each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3;
- and
- Y is zero, 1, or 2.
Dependencies are inferred from the claim text.