Controlling sample dilution from injection apparatus to flow cell for measuring mobility of sample
AssigneeWyatt Technology Corporation
InventorsShivakumar Ramini, Anthony John Clemens, Steven P. Trainoff
Life of this patent
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Abstract
Systems and methods for controlling sample dilution in an analytical instrument system comprise transmitting an injection command to an autosampler to inject a predetermined volume of air into a sample tubing coupled to an analytical instrument; and transmitting, subsequent to the injection of the predetermined volume of air, a fill command to the autosampler to aspirate a volume of sample into the sample tubing, wherein the predetermined volume of air is configured to form an immiscible barrier between the volume of sample and a solvent within the sample tubing.
Claims20
A computer-implemented method for controlling sample dilution in an analytical instrument system, the method comprising:
- transmitting an injection command to an autosampler to inject a predetermined volume of air into a sample tubing coupled to an analytical instrument resulting in an air injection;
- and
- transmitting a fill command to the autosampler to aspirate a volume of sample into the sample tubing, wherein the predetermined volume of air is configured to form an immiscible barrier between the volume of sample and a solvent within the sample tubing.
An autosampler system for controlling sample dilution in analytical measurements, the autosampler system comprising:
- an injection loop comprising a column having a tubular housing with an inlet and an outlet;
- and
- a plurality of closely packed spherical beads disposed within the tubular housing, wherein the plurality of closely packed spherical beads are configured to disrupt parabolic Poiseuille flow and create a tortuous flow path with multiple interstitial flow channels.
A system for controlling sample dilution in analytical measurements, the system comprising:
- an autosampler configured to inject samples into a sample tubing;
- the sample tubing coupled between the autosampler and an analytical instrument;
- and
- a computer processor configured to transmit commands to perform an air injection that includes an injection of a predetermined volume of air into the sample tubing to form an immiscible barrier that maintains separation between a sample and a carrier solvent during transport.
Dependencies are inferred from the claim text.