Container closure integrity testing method and system

A container closure integrity (CCI) testing system for testing tightness of a stopper closure of a syringe, wherein the syringe has a syringe body with a longitudinal axis, a hollow interior extending between an open first axial end and a second axial end with an orifice, and an elastic stopper provided through the open first axial end into the hollow interior such that a chamber is formed between the stopper and the second axial end, the CCI testing system comprising:

• a detection gas reservoir configured to enclose a detection gas;
• a detection gas sensor;
• a processing unit having a gas chamber, a positioning structure and a movement structure;
• and
• a connector arrangement
• wherein the gas chamber of the processing unit is connected to the detection gas reservoir and configured to house detection gas provided by the detection gas reservoir;
• wherein the positioning structure of the processing unit is configured to hold the syringe such that one of the open first axial end of the syringe body and the orifice of the second axial end of the syringe body is arranged in the gas chamber;
• wherein the movement structure of the processing unit is configured to move the stopper in the hollow interior of the syringe body when the syringe is held by the positioning structure of the processing unit;
• wherein the connector arrangement is configured to connect the other one of the open first axial end of the syringe body and the orifice of the second axial end of the syringe body to the detection gas sensor when the syringe is held by the positioning structure of the processing unit;
• and
• wherein the detection gas sensor is configured to sense for detection gas exiting the chamber of the syringe while moving the stopper in the hollow interior of the syringe body.