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US 2026/0152811 A1Published application
Methods for analyzing viral nucleic acid
AssigneeGrail, LLC
InventorsYuk-Ming Dennis LO, Kwan Chee CHAN, Weng In CHU
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Abstract
Provided herein are methods, systems, and computer readable medium for detecting nucleic acid from a pathogen, e.g., virus, e.g., Epstein-Barr virus (EBV), in a cell-free nucleic sample from an individual at risk of a condition, e.g., nasopharyngeal carcinoma (NPC). The methods, systems, and computer readable medium can be used to screen for the presence of the condition, e.g., NPC, using thresholds adjusted based on sample attributes.
Claims19
-31. (canceled)
A method of screening a subject for a tumor, the method comprising:
- performing an assay of a biological sample of the subject measuring an amount of cell-free nucleic acid from a virus in the biological sample, and
- identifying the amount of viral cell-free nucleic acid in the biological sample as being above a threshold amount;
- wherein:
- (a) the threshold amount distinguishes reference biological samples of reference subjects with a known tumor from reference biological samples of reference subjects without the known tumor;
- (b) the tumor of the subject comprises nucleic acid of the virus;
- and
- (c) the subject and the reference subjects are humans characterized by one or more of the following:
- (i) age above 45 years old;
- or (ii) smoking status is a smoker.
6 more elements
Dependencies are inferred from the claim text.