Back to results
US 2026/0152576 A1Published application
HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS
AssigneeXencor, Inc.
InventorsGregory L. Moore, Gregory Lazar
Life of this patent
Estimating the term…
Abstract
The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains.
Claims2
A composition comprising a variant human IgG1 Fc region, wherein the variant human IgG1 Fc region is a variant of the wild-type human IgG1 Fc region, wherein the variant human IgG1 Fc region comprises amino acid modifications consisting of K447del, L351K, and T366K, and wherein numbering is according to the EU index.
-10. (canceled)
Dependencies are inferred from the claim text.