Antibodies that specifically bind to human il-15 and uses thereof
AssigneeCephalon, Inc.
InventorsDavid Jose Simon LAINE, Matthew POLLARD, Anthony Gerard DOYLE, Adam William CLARKE, Lynn Dorothy POULTON
Life of this patent
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Abstract
Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.
Claims27
An antibody, comprising a variable heavy chain and a variable light chain, wherein the antibody specifically binds to an epitope comprising the Q108 residue of human IL-15, wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα).
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A method of treating Celiac disease in a subject in need thereof, comprising administering to the subject an antibody that binds to IL-15, wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα).
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Dependencies are inferred from the claim text.