Method for producing gamma delta t cells
AssigneesKyoto University, Takeda Pharmaceutical Company Limited
InventorsShin Kaneko, Shoichi Iriguchi, Tatsuki Ueda, Yoshiaki Kassai, Akira Hayashi, Kazuhide Nakayama
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Abstract
The present invention provides a method for producing a γδT cell from an induced pluripotent stem cell, wherein the induced pluripotent stem cell is derived from a cell other than an αβT cell.
Claims19
1-21. (canceled)
A method for producing a γδT cell from an induced pluripotent stem cell derived from a cell other than an αβT cell,
- wherein the method comprises the following steps (1) and (2):
- (1) a step for establishing an induced pluripotent stem cell from a cell other than an αβT cell, and
- (2) a step for differentiating the induced pluripotent stem cell established in step (1) into a T cell, and
- wherein the γδT cell is a CD8α+β+ cell.
A γδT cell derived from an induced pluripotent stem cell derived from a cell other than an αβT cell, wherein the γδT cell is a CD8α+β+ cell.
A cell population in which not less than 90% of all cells are γδT cells, wherein the γδT cell is a CD8α+β+ cell and a cell differentiated from an induced pluripotent stem cell derived from a cell other than an αβT cell.
Dependencies are inferred from the claim text.