Combination inhibitors for treating fibrosis
AssigneesMemorial Sloan Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research, Memorial Hospital for Cancer and Allied Diseases
InventorsCraig B. Thompson, Simon Schwoerer
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Abstract
Aspects of the present disclosure relate to the discovery that antagonizing pyruvate carboxylase and glutaminase inhibits cell proliferation and extracellular matrix production. Thus, methods and compositions disclosed herein may be used to treat fibrotic disease and cancer by inhibiting cell proliferation and extracellular matrix production.
Claims81
A method of inhibiting collagen synthesis by a fibroblast, the method comprising contacting the fibroblast with an antagonist of pyruvate carboxylase (PC) and an antagonist of glutaminase.
A method of treating a fibrotic disorder, the method comprising:
- administering to a subject in need thereof an antagonist of pyruvate carboxylase (PC) in an amount effective to inhibit extracellular matrix (ECM) protein production, wherein the subject is also receiving an antagonist of glutaminase.
A method of treating a fibrotic disorder, the method comprising:
- administering to a subject in need thereof an antagonist of glutaminase in an amount effective to inhibit extracellular matrix (ECM) protein production, wherein the subject is also receiving an antagonist of pyruvate carboxylase (PC).
A method of treating a fibrotic disorder, the method comprising:
- administering to a subject in need thereof an antagonist of pyruvate carboxylase (PC) and an antagonist of glutaminase in an amount effective to inhibit extracellular matrix production.
A method of inhibiting tumor cell proliferation, the method comprising contacting the tumor cell with an antagonist of pyruvate carboxylase (PC) and an antagonist of glutaminase.
A method of treating a cancer, the method comprising:
- administering to a subject in need thereof an antagonist of pyruvate carboxylase (PC) in an amount effective to inhibit carcinogenesis, wherein the subject is also receiving an antagonist of glutaminase.
A method of treating a cancer, the method comprising:
- administering to a subject in need thereof an antagonist of glutaminase in an amount effective to inhibit carcinogenesis, wherein the subject is also receiving an antagonist of pyruvate carboxylase (PC).
A composition comprising an antagonist of pyruvate carboxylase (PC) and an antagonist of glutaminase.
A kit comprising:
- an antagonist of PC;
- an antagonist of glutaminase;
- and
- instructions for use of the antagonist of PC and the antagonist of glutaminase.
Dependencies are inferred from the claim text.