Recombinant activation-associated secreted protein
AssigneesUniversiteit Gent, Academisch Ziekenhuis Leiden, Wageningen Universiteit
InventorsPeter GELDHOF, Laurens ZWANENBURG, Jimmy BORLOO, Ruud Hendrikus Petrus WILBERS, Cornelis Hendrik HOKKE, Angela VAN DIEPEN
Life of this patent
Estimating the term…
Abstract
The present invention relates to a recombinant activation-associated secreted protein (ASP) or fragment thereof, said ASP or fragment comprising an N-glycan comprising a core α1,3-fucose and/or a core α1,6-fucose (Fuc). The invention further relates to a pharmaceutical composition comprising such a recombinant ASP or fragment thereof. Additionally, the invention relates to the recombinant ASP or fragment thereof for use as a human or veterinary medicine, in particular as a vaccine, more in particular for use against parasitic nematode infections.
Claims14
A recombinant activation-associated secreted protein (ASP) or fragment thereof, said ASP or fragment thereof comprising an N-glycan comprising a core α1,3-fucose and/or a core α1,6-fucose, GlcNAc, and Man in the conformation of structure (Ia) or (Ib)
- and wherein X and/or Y are absent, or independently from each other substituted with N-acetylglucosamine (GlcNAc), galactose (gal), fucose (fuc), or mannose (man), and combinations thereof.
Dependencies are inferred from the claim text.