A method for synthesizing a peptide comprising one or more amino acid having a functional group in a side chain thereof, 50% or more of hydrophobic amino acid, and 10% or less of amino acid in which an α-amino group is a secondary amino group;
- or a peptide comprising one or more amino acid having a functional group in a side chain thereof, and 21 or more of amino acid residues,
- wherein a carrier for peptide synthesis represented by a general Formula (1) below is introduced into the side chain of the amino acid having a functional group in a side chain thereof:
- wherein,
- R1 is a hydrogen atom;
- or when Rb is a group represented by Formula (a) below, R1 is a fluorene ring taken together with Formula (a), a xanthene ring taken together with Formula (a) via an oxygen atom, or a 9,10-dihydroanthracene ring taken together with Formula (a) via a methylene group;
- p R2's each independently represent a group represented by Formula (2);
- R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms;
- X2 represents O or CONR17 (wherein R17 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms);
- and
- A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12) or (13),
- wherein, R18, R19, and R20 are the same or different and each represent a linear or branched alkyl group having 1 to 6 carbon atoms or an aryl group optionally having a substituent;
- and R21 represents a single bond or a linear or branched alkylene group having 1 to 3 carbon atoms, and R22, R23, and R24 each represent a linear or branched alkylene group having 1 to 3 carbon atoms,
- q R3's each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms;
- p represents an integer of 1 to 4, and q represents an integer of 0 to 3;
- and
- Ra and Rb each independently represent a hydrogen atom, a linear or branched alkyl group having 1 to 4 carbon atoms, an aralkyl group, or a group represented by Formula (a);
- wherein, * represents a bonding site;
- R11 may be a hydrogen atom;
- or may form a fluorene ring taken together with R1 in Formula (1), a xanthene ring taken together with R1 in Formula (1) via an oxygen atom, or a 9,10-dihydroanthracene ring taken together with R1 in Formula (1) via a methylene group;
- r R12's each independently represent a group represented by Formula (2) above (R6, X2, and A in Formula (2) are the same as described above);
- s R13's each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms;
- and
- s represents an integer of 1 to 4 and r represents an integer of 0 to 3, and Y represents a hydroxy group, NHR25 (R25 represents a hydrogen atom, an alkyl group, or an aralkyl group), or a halogen atom.