Heteroaryl compounds, preparation methods and uses thereof

A compound of Formula I, or a pharmaceutically acceptable salt thereof:

• wherein:
• L1 is NR11,
• or null;
• L2 is optionally substituted C1-4 alkylene, optionally substituted C1-4 heteroalkylene, optionally substituted C3-6 cycloalkylene, optionally substituted 4-6 membered heterocyclylene, or NH;
• X2 is O or NR13;
• represents an optionally substituted 6-membered heteroaryl ring,
• wherein:
• J1 is CR14 or N;
• J2 is CR15 or N;
• J3 is CR16 or N;
• J4 is N;
• and
• J5 is C;
• wherein:
• R1 is hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C2-6 alkynyl, an optionally substituted C1-6 heteroalkyl, an optionally substituted C3-10 carbocyclic ring, an optionally substituted 4-10 membered heterocyclic ring, an optionally substituted phenyl, or an optionally substituted heteroaryl;
• R2 is hydrogen, CD3, an optionally substituted C1-4 alkyl, or an optionally substituted C1-4 heteroalkyl;
• R3 is hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 heteroalkyl, or a nitrogen protecting group;
• R4 is hydrogen, an optionally substituted C1-6 alkyl, or an optionally substituted C1-6 heteroalkyl;
• wherein:
• each of R11, R12, and R13 is independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-4 heteroalkyl, or optionally substituted C3-6 cycloalkyl;
• or R11 and R12, together with the intervening atoms, are joined to form an optionally substituted 5-8 membered ring structure;
• R14, R1, and R16 are each independently halogen, RA, ORA, SRA, S(O)RA, S(O)2RA, CORA, COORA, CN, NRBRC, CONRBRC, S(O)2NRBRC, or NO2,
• wherein RA at each occurrence is independently hydrogen, an optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-8 carbocyclyl, optionally substituted C1-4 heteroalkyl, optionally substituted 4-8 membered heterocyclyl, optionally substituted 5 or 6 membered heteroaryl, or optionally substituted phenyl,
• wherein each of RB and RC at each occurrence is independently RA, —C(O)—RA, —COORA, S(O)2RA, CONRB′RC′, wherein each of RB and RC′ is independently RA;
• or RB and RC together with the nitrogen they are both attached to are joined to form an optionally substituted 4-8 membered ring structure;
• or R4 and R13, as applicable, together with the intervening atoms, are joined to form an optionally substituted 5-8 membered ring structure;
• or R4 and R14, R13 and R14, R14 and R15, or R15 and R16, as applicable, together with the respective intervening atoms, are joined to form an optionally substituted 5-8 membered ring structure.