Reversible radiopaque occlusive compositions and methods for implanting them
AssigneeContraline, Inc.
InventorsYelena Tropsha, Nicholas Matsumoto, Tyler Chiartas, Kevin S. Eisenfrats
Life of this patent
Estimating the term…
Abstract
Compositions, devices, and methods of using one or more hydrogel for contraception are disclosed. In embodiments, the compositions and devices comprise one or more contrast agent, rendering the compositions and devices radiopaque. Included are compositions for an occlusive implant comprising: a multi-arm polyethylene glycol terminated with a thiol crosslinked with a multi-arm polyethylene glycol terminated with a maleimide; and one or more contrast agent. The devices/hydrogel may be used for occlusion of a bodily duct, such as the vas deferens and/or fallopian tubes, for male and female contraception, respectively.
Claims26
1-2. (canceled)
A composition comprising:
- a first component comprising polyethylene glycol terminated with a first crosslinkable functional group;
- and
- a second component comprising polyethylene glycol terminated with a second crosslinkable functional group;
- wherein the first component and/or the second component further comprises one or more contrast agent;
- and
- wherein the first component and the second component, upon mixing, are capable of forming a covalently cross-linked hydrogel as an end composition.
(canceled)
9-11. (canceled)
(canceled)
15-17. (canceled)
22-25. (canceled)
A method of implanting a hydrogel composition, the method comprising:
- identifying a target region within a body;
- injecting a selected volume of a test composition into the target region;
- visualizing the target region and the injected volume of the test composition using imaging;
- removing the test composition from the target region;
- selecting a desired length for an implanted hydrogel based on the visualizing;
- determining an injection volume of a composition capable of forming the hydrogel that corresponds to the desired length for the implanted hydrogel;
- and
- injecting the composition capable of forming the hydrogel into the target region.
34-37. (canceled)
Dependencies are inferred from the claim text.