Instrument for use in blood vessel, and coating agent
AssigneeJapan Medical Device Startup Incubation Program
InventorsNaoki INUZUKA, Yuji TERAMURA, Yuya SATO
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Abstract
Provided are an instrument and a coating agent for use in blood vessels, which can be stably supplied, have excellent suppression of clot formation, and are unlikely to inhibit vascular endothelialization. The instrument according to the present invention comprises a base material and a coating layer that covers at least a part of the surface of the base material, and is intended to be used in a blood vessel. The coating layer has a monomolecular layer formed by treating the surface of the base material with a low-molecular-weight compound having a functional group such as an albumin-binding functional group, and satisfies at least one of predetermined requirements.
Claims10
A device for use inside a blood vessel, the device comprising:
- a base material;
- and a coating layer at least partially covering a surface of the base material,
- the coating layer comprising a monomolecular layer resulting from surface treatment of the base material with a low-molecular-weight compound having an albumin-binding functional group,
- the device satisfying at least one of conditions:
- (1) the coating layer includes the monomolecular layer at its uppermost surface with no polymer layer on a surface of the monomolecular layer,
- (2) the coating layer has an average thickness of 30 nm or less, and
- (3) the coating layer has a surface with at least one of a Si content of 0.5 atm % or more or a P content of 0.5 atm % or more as measured by X-ray photoelectron spectroscopy.
A device for use inside a blood vessel, the device comprising:
- a base material;
- and a coating layer at least partially covering a surface of the base material,
- the coating layer comprising a monomolecular layer resulting from surface treatment of the base material with a low-molecular-weight compound having at least one functional group selected from the group consisting of an amino group, a halogen group, a carboxy group, and an alkyl group,
- the device satisfying at least one of conditions:
- (1) the coating layer includes the monomolecular layer at its uppermost surface with no polymer layer on a surface of the monomolecular layer,
- (2) the coating layer has an average thickness of 30 nm or less, and
- (3) the coating layer has a surface with at least one of a Si content of 0.5 atm % or more or a P content of 0.5 atm % or more as measured by X-ray photoelectron spectroscopy.
Dependencies are inferred from the claim text.