Synthesis and characterization of glycosaminoglycan mimetic variants to promote chondrogenesis
AssigneesThe Trustees of Columbia University in the City of New York, New Jersey Institute of Technology
InventorsTreena Arinzeh, Richard Vincent, George Collins
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Abstract
Compositions and methods for improving chondrogenesis, or treating osteoarthritis, or treating joint degradation or treating an osteochondral defect in a subject.
Claims20
A composition for chondrogenesis or chondral repair or osteochondral repair, comprising a sulfated chitin, a sulfated starch, a sulfated cellulose or a sulfated dextran and, optionally, a carrier.
An injectable fiber composition for chondrogenesis or articular cartilage repair or treating a chondral or osteochondral defect, the injectable fiber composition comprising a sulfated chitin, a sulfated starch, a sulfated cellulose or a sulfated dextran, and a carrier.
A scaffold for chondrogenesis or articular repair comprising sulfated starch with a degree of sulfation of 1.5 per monomer of starch.
Dependencies are inferred from the claim text.