Radiopharmaceutical mofs for medical imaging
AssigneeNode Pharma AS
InventorsSigurd ØIEN-ØDEGAARD, Erik MJÅLAND, Tor Espen STAV-NORAAS
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Abstract
The present invention relates to MOFs for use in imaging and as radiolabeled tracers. More particularly, the invention provides a particle comprising a MOF, optionally at least one targeting moiety and at least one short-lived radionuclide; a composition comprising said particle; said particle or composition for use as an imaging agent; said particle or composition for use in a method for the diagnosis of a proliferative disease; said particle or composition for use in a method for the diagnosis of a chronic inflammatory disease; and a kit comprising a particle comprising a MOF, an optional targeting moiety, and a short-lived radionuclide cation.
Claims20
A particle comprising
- a MOF, wherein the MOF comprises
- a repeating three-dimensional network of inorganic monomers and organic monomers, forming pores, and
- at least one free functional group that extends into a pore, wherein the functional group is selected from the group consisting of carboxylic acid, carboxylate, hydroxyl, sulfonic acid, sulfonate, sulfhydryl, primary amines, secondary amines, and combinations thereof;
- optionally at least one targeting moiety connected to the particle on an external surface of the particle;
- and
- at least one short-lived radionuclide, wherein the radionuclide is a radionuclide cation with a half-life in the range of 0.5 hours to 60 days;
- and wherein the at least one radionuclide is located in at least one of the pores.
(canceled)
A kit comprising,
- in a first container,
- a particle comprising
- a MOF, wherein the MOF comprises
- a repeating three-dimensional network of inorganic monomers and organic monomers, forming pores, and
- at least one free functional group that extends into a pore, wherein the functional group is selected from the group consisting of carboxylic acid, carboxylate, hydroxyl, sulfonic acid, sulfonate, sulfhydryl, primary amines, secondary amines, and combinations thereof;
- optionally at least one targeting moiety connected to the particle on an external surface of the particle;
- and
- in a second container,
- a short-lived radionuclide, wherein the radionuclide is a radionuclide cation with a half-life in the range of 0.5 hours to 60 days.
(canceled)
Dependencies are inferred from the claim text.