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US 2026/0151455 A1Published application
Altering inflammatory states of immune cells in vivo by modulating cellular activation states
AssigneeFred Hutchinson Cancer Center
InventorMatthias Stephan
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Abstract
Systems and methods to modulate the activation state of immune cells in vivo are described. The systems and methods can be used to transform immunosuppressive macrophages that support cancer growth and metastasis into highly activated tumoricidal macrophages.
Claims13
A method of altering an activation state of immune cells in vivo comprising:
- administering nanoparticles comprising nucleotides encoding one or more interferon regulatory factors (IRFs) to a subject thereby altering the activation state of immune cells in vivo.
Dependencies are inferred from the claim text.