Peptide-lipid conjugates and application thereof
AssigneeVacino Biotech Co., Ltd.
InventorsJia-Ming CHANG, I-Hua LIU
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Abstract
A peptide-lipid conjugate is provided. The conjugate includes a peptide selected from SEQ ID NO: 1 to SEQ ID NO: 29 and a hydrophobic carbon chain conjugated to the peptide. The conjugate further includes a lipid-based carrier encapsulating at least one reagent, and the hydrophobic carbon chain anchors into a lipid layer of the lipid-based carrier. The peptide can bind to a transferrin receptor (TfR), and binding of the peptide to transferrin receptors on cells of a tissue barrier induces transcytosis of the cells, thereby transporting the conjugate across the tissue barrier. Thus, the conjugate can serve as a drug delivery system.
Claims20
A peptide-lipid conjugate, comprising:
- a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 29;
- and
- a hydrophobic carbon chain conjugated to the peptide.
A method of transporting at least one reagent to a target, comprising binding a peptide-lipid-(lipid-based carrier) conjugate to a transferrin receptor, wherein the peptide-lipid-(lipid-based carrier) conjugate comprises:
- a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 29;
- a hydrophobic carbon chain conjugated to the peptide;
- and
- a lipid-based carrier encapsulating the at least one reagent;
- wherein a first carbon or a last carbon of the hydrophobic carbon chain is conjugated to a lysine of the peptide, and the hydrophobic carbon chain anchors into a lipid layer of the lipid-based carrier.
Dependencies are inferred from the claim text.