Systems, devices, and methods for ablation and defunctionalization of a gallbladder

A system, comprising:

• an outer shaft including a distal end that is disposable within a body cavity;
• an inner shaft configured to be inserted into the body cavity via the outer shaft, the inner shaft configured to deliver a cryogenic ablation medium into the body cavity;
• and
• a first lumen configured to deliver a fluid to dehumidify the body cavity and reduce freezing of fluids during evacuation of the fluids from the body cavity.

A system, comprising:

• a shaft disposable within a body cavity, the shaft including:
• a first lumen configured to deliver a cryogenic ablation medium into the body cavity;
• and
• a second lumen terminating within the body cavity configured to be in fluid communication with a pump to drive a low-freezing point fluid to dehumidify the body cavity and reduce freezing of fluids during evacuation of the fluids from the body cavity.