US 2026/0147200 A1 · HIGH THROUGHPUT OPTICAL IMAGER

Abstract

In various aspects, microscope systems are described, comprising or corresponding to optical microscopes, such as for example a transillumination microscope or a fluorescence microscope. The microscope systems may be used independently or configured with or integrated into another device or system, such as an imaging mass spectrometer or imaging mass cytometer. In various embodiments of this aspect, the microscope system is used to obtain one or more images of a sample, such as at a variety of different light collection wavelengths and/or for a variety of different illumination conditions. The microscope systems can employ various optical components and configurations allowing for high throughput imaging, such as components for imaging the sample at suitable resolutions with a wide field of view and/or for spatially separating different detection channel wavelengths from light output (e.g., transmitted or emitted light) from the sample.

Claims31

Dependent claims

A system comprising:

a sample holder;
a light source positioned to direct illumination onto a sample in the sample holder;
light collection optics positioned to receive output light from the sample, the light collection optics comprising a plurality of beamsplitters arranged to separate the output light from the sample into a plurality of detection channels spatially separated from one another, wherein different detection channels of the plurality of detection channels correspond to different wavelengths or wavelength bands of the output light;
and
a plurality of photosensors, each photosensor respectively positioned in optical communication with one or more beamsplitters to image output light from the sample at a corresponding detection channel onto the photosensor.

2 more elements

Dependencies are inferred from the claim text.

High throughput optical imager

Life of this patent

High throughput optical imager

Life of this patent

Abstract

Claims31