Device and sensor for detection of an analyte

A sensor for detection of an analyte in a sample, wherein the sensor comprises:

• a substrate;
• an electrochemical cell disposed on the substrate, wherein the electrochemical cell comprises:
• a working electrode comprising:
• a recognition layer disposed on a surface of the working electrode capable of binding to the analyte;
• a reference electrode;
• and
• a counter electrode;
• wherein binding of the analyte to the recognition layer comprises:
• binding of the analyte to a nuclear receptor immobilized on the recognition layer thereby inducing a conformation change;
• or
• binding of the analyte to a binding cavity complementary to the analyte;
• and
• a measurement circuit operably coupled to the electrochemical cell wherein the measurement circuit is configured to:
• i) apply a potential to the working electrode;
• and
• ii) detect a change in an electrical property at the working electrode caused by the binding of the analyte to the recognition layer, wherein said binding is correlative to a concentration of the analyte in the sample.