Udp-sugar bioproduction using microorganism hosts
AssigneeDebut Biotechnology, Inc.
InventorsNicholas Brideau, Jingyi Li, Johannes Van Dijk
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Abstract
The present invention is directed to compositions and methods for production of UDP-sugars, including UDP-glucose and UDP-galactose. In particular, the invention provides engineered cell lines for production of UDP-sugars and methods of production of UDP-sugars with these engineered cell lines.
Claims36
An engineered host cell that comprises one or more genetic modifications that result in enzymatic transformation by the engineered host cell of a carbon source through multiple chemical intermediates into a UDP-sugar, wherein the UDP-sugar is UDP-glucose or UDP-galactose.
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A method of increasing the production of UDP-sugar, the method comprising:
- providing an engineered host cell that comprises one or more genetic modifications that result in enzymatic transformation by the engineered host cell of a carbon source through multiple chemical intermediates into a UDP-sugar, wherein the UDP-sugar is UDP-glucose or UDP-galactose.
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Dependencies are inferred from the claim text.