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US 2026/0146266 A1Published application
Recombinant host cells and methods for the production of glycolic acid
OwnerJeffrey A. Dietrich, Mario Ouellet +2inventors
InventorsJeffrey A. Dietrich, Mario Ouellet, Johan Van Walsem, Andrew Conley
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Abstract
Methods and materials related to producing glycolic acid are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
Claims50
A recombinant host cell comprising a glycolic acid biosynthetic pathway:
- wherein the glycolic acid biosynthetic pathway comprises heterologous nucleic acids encoding an oxaloacetate-forming enzyme, a malate dehydrogenase, a malate-CoA ligase, a malyl-CoA lyase, and a glyoxyate reductase;
- wherein the heterologous nucleic acids are expressed in sufficient amounts to produce glycolic acid.
Dependencies are inferred from the claim text.