Tertiary amide aldonamide based ice recrystallization inhibitor compounds and compositions, and uses thereof for cryopreservation

A compound of formula (I):

• its enantiomer, diastereomer, or its physiologically acceptable salt thereof,
• wherein
• Q and J are each selected from the group consisting essentially of:
• an unmodified C1-9-alkyl,
• an unmodified phenyl,
• a mono substituted C1-9-alkyl,
• a mono substituted phenyl,
• a di substituted C1-9-alkyl, and
• a di-substituted phenyl,
• wherein any substitution within such C1-9-alkyl or phenyl is selected from the group consisting essentially of:
• a C1-4-alkyl;
• a C1-4-alkoxy;
• a —NH2;
• —NR5H, wherein R5 is selected from the group consisting essentially of:
• a H;
• an alkyl;
• and
• an aryl;
• and
• —N(R6)2, wherein each R6 is selected from the group consisting essentially of:
• a —C(O)R7;
• a —C(═O)OR8;
• a —C(═O)H;
• and
• a halogen,
• wherein R7 and R8 are each selected from the group consisting essentially of:
• a H;
• an alkyl;
• and
• an aryl;
• R1, R2, R3 and each R4 are each selected from the group consisting essentially of:
• a —H,
• a —OH,
• a —OR9,
• a —NHR10, and
• a —N(R11)2,
• wherein R10 and R11 are each selected from the group consisting essentially of:
• a H,
• an alkyl, and
• an aryl;
• Ra is selected from the group consisting essentially of:
• a —H,
• an unmodified C1-4-alkyl;
• an unmodified phenyl;
• a heteroatom-modified C1-4-alkyl;
• and
• a heteroatom-modified phenyl;
• n is an integer from 1 to 7, wherein when n is greater than 1, the R4 on the carbon atom attached to ORa is H.